Contrast-enhanced ultrasound guided pleural biopsy improves diagnostic confidence for pleural based lesions: a 3-year prospective study

Abstract Objective To evaluate the accuracy and safety of contrast-enhanced ultrasound (CEUS) guided biopsy in diagnosis radiologically determined pleural based lesions. Method A prospective study was conducted on patients with Patients who met inclusion criteria received by CEUS to obtain specimens, followed histomathological microbiological examinations. After treatment follow-up, surgical thoracoscopy performed cases undefinite diagnosis. Result total 460 were finally included. showed internal necrosis 72.17% obvious peripheral vessels 55.43% cases, both which significantly higher than conventional imaged ( p < 0.05). The diagnostic through sampling 98.91% (455/460). yield achieved 71.88% (225/313) infectious In 330 combined effusion, increased from 60.30% (199 /330) 98.36% (325 all 0.05), 15.56% (14/90) 94.44% (85/90) malignant lesions 0.01) 77.08% (185/240) 100% (240/240) No serious adverse events occurred. Conclusion provides a minimally invasive, effective safe method for Clinical Trials Registration : Chinese Trial Registry ChiCTR2000029749 (ChiCTR, www.chictr.org.cn ).